Glucose 5% Solution for Intravenous Infusion 500ML is a sterile, pyrogenic and isotonic solution for intravenous administration, used mainly for fluid restoration and hydroelectrolyte balance. The product consists exclusively of glucose dissolved in purified water, ensuring rapid availability of energy that is easily assimilated by the body. The infusion is particularly suitable for patients who need a rapid supply of glucose, to support the metabolism during the treatment of conditions such as hypoglycemia or dehydration. The solution, free of electrolytes and pharmacological agents, allows optimal tolerance and safe use in numerous clinical contexts, including emergency departments, intensive care and general medicine. Each 500ML bottle is designed to facilitate controlled and sterile administration, minimizing the risk of contamination. The ready-to-use format reduces preparation time for healthcare personnel and is indicated in adult, elderly and pediatric patients, following assessment of specific needs.
The 5% Glucose Solution can be administered alone or as a vehicle for the dilution or administration of compatible drugs, according to the medical prescription. Being an isotonic solution, it is used both in routine hospital treatments and in particular emergency situations, where it is necessary to quickly re-establish adequate energy and water values. The 500ML package represents an optimal format to guarantee an adequate duration of administration, adapting to different clinical needs, from rapid to progressive and continuous administration.
Therapeutic Indications
Glucose 5% Solution for Intravenous Infusion is indicated in the treatment and prevention of dehydration, especially in cases where the patient is unable to take liquids orally. It is also used to provide a rapid energy supply in cases of hypoglycemia, i.e. when there is a critical deficit of glucose in the blood which could lead to tiredness, mental confusion, loss of consciousness or convulsions. It is used as a support solution in many clinical situations that require parenteral caloric intake, in combination or complement with other electrolyte or amino acid solutions, especially in total parenteral nutrition.
This solution is also used for the dilution and administration of drugs intravenously, if the compatibility between glucose and the active ingredient is proven. It is an appropriate choice both during the post-operative period, to facilitate the recovery of water and energy balance, and in the treatment of infectious, metabolic or systemic pathologies that lead to a reduction in energy reserves. Glucose 5% can be administered to patients of all ages, including children and the elderly, under the supervision of medical and healthcare personnel.
In clinical practice it is also used as a carrier solution for the administration of compatible medicines, therefore representing a fundamental tool in intravenous therapeutic procedures. It can also be used in the temporary treatment of diabetic ketoacidosis if it is necessary to simultaneously correct dehydration and supplement glucose loss, always under medical monitoring. It is therefore indicated in numerous acute and chronic conditions in which the rapid replenishment of carbohydrate energy or the restoration of plasma volume play a priority role.
Composition
Active ingredient: Glucose monohydrate 50 g per liter (equivalent to anhydrous glucose 45 g/l). Each 500ML bottle therefore contains 25 g of glucose monohydrate dissolved in purified water, chemical formula C6H12O6.
Excipients: Water for injections to taste. for 500ML. It contains no preservatives, electrolytes or other additives. The final solution is pyrogen-free and guaranteed to be sterile and pyrogen-free until the bottle is opened. The pH of the solution is generally between 3.5 and 6.5, to facilitate compatibility with blood and minimize local or systemic adverse reactions.
The solution is transparent, free of visible particles and odorless. Each production batch is rigorously controlled to ensure the purity and safety of the product. The organoleptic properties and composition make this solution suitable both as a single infusion and as a base for mixing with other parenteral preparations, according to specific therapeutic needs.
Contraindications
The administration of Glucose 5% Solution for Intravenous Infusion is contraindicated in case of known hypersensitivity to glucose or to any of the excipients. It is also contraindicated in subjects with clinically significant hyperglycemia, i.e. excessive blood sugar levels that could worsen with the administration of glucose. It must not be administered to patients with uncontrolled diabetes, diabetic coma or other conditions in which glucose infusion may aggravate the underlying disease.
Further contraindications concern patients with metabolic problems that prevent the optimal use of glucose, such as congenital galactosemia, glucose-galactose malabsorption and isomaltase-succrase deficiency. Do not use in cases of overhydration, congestive heart failure, pulmonary edema or conditions in which an increase in extracellular fluids is counterproductive. In the case of significant alteration of renal function, the administration of the solution must be carefully evaluated.
The solution should not be used as a vehicle for drugs that are chemically and physically incompatible with glucose or aqueous solution. The infusion must be stopped immediately in case of adverse reactions, signs of local intolerance, marked edema or other clinical complications. Constant monitoring of metabolic and vital parameters is essential in patients at risk.
Security of the Solution for the Human Species
Glucose 5% Solution for Intravenous Infusion is generally well tolerated when administered according to clinical indications and under close medical supervision. The safety profile is high thanks to the absence of preservatives, the sterility of the solution and its isotonic formulation, which reduces the risk of hemolysis and local inflammatory reactions. However, administration must take place by trained personnel in a healthcare environment to ensure constant monitoring for any signs of fluid overload, electrolyte imbalances or metabolic alterations.
In particularly sensitive patients, such as diabetics, blood sugar monitoring is a priority to avoid hyperglycemic peaks which could lead to complications such as ketoacidosis or hyperosmolar state, especially in the case of underlying pathologies that are not completely compensated. Prolonged use must be accompanied by the monitoring of laboratory parameters such as sodium, potassium and renal function, to prevent metabolic and/or hydroelectrolyte disorders. The solution is compatible with the administration of numerous intravenous drugs, but miscibility must be verified before combined administration.
In patients in a critical state or with renal failure, administration must be conducted with particular caution and under the evaluation of medical specialists, avoiding volume overload which can lead to cardiovascular or pulmonary complications. The safety of use is also confirmed in the elderly and children, albeit with specific evaluation of the doses and particular clinical conditions of the patient.
Precautions
The solution must be administered exclusively intravenously, absolutely avoiding different uses or administration by other routes. Before administration, check that the bottle is intact, the solution is clear and free of particulates. Do not use if the solution appears cloudy, discolored or if the container shows signs of damage. The infusion must be carried out at a controlled rate and adjusted according to the clinical conditions, age and weight of the patient, as well as the blood chemistry parameters found during therapy.
In the case of prolonged infusions or critically ill patients, periodic evaluation of plasma glucose, sodium, potassium and other electrolyte levels is recommended, to prevent adverse events such as hyperglycemia, electrolyte imbalances or fluid overload. Each drug added to the solution must be mixed exclusively under aseptic conditions, after checking the compatibility between the products.
In subjects with renal, cardiac or pulmonary impairment, or in the presence of pathologies that cause water retention, the infusion rate and volume must be adapted under close medical supervision. The bottle must be used only once, and any residue eliminated in accordance with current health procedures. Always wash your hands after handling the solution and adopt all health and hygiene rules to avoid contamination. Keep out of the sight and reach of children.
Method of Administration
Glucose 5% Solution for Intravenous Infusion should be administered exclusively by infusion into a vein, preferably via peripheral or, where necessary, central venous catheterization. The infusion rate must be carefully adjusted based on the patient's clinical status and blood chemistry parameters, with particular attention in pediatric or elderly subjects. In acute conditions, rapid administration is possible to bring immediate correction of blood sugar; in supportive treatments administration must be slower and more constant.
Before use, make sure the solution is clear and the bottle intact. Carefully disinfect the needle insertion area and use only sterile material for each procedure. After inserting the needle, connect the solution to the infusion set and adjust the speed using the appropriate drip regulator, following the medical instructions. If it is necessary to dilute drugs, add them to the solution exclusively under aseptic conditions, mixing gently without shaking vigorously.
At the end of administration, remove the needle carefully and lightly compress the insertion area to prevent bleeding or bruising. Discard any residue of unused solution according to hospital and environmental regulations. Do not reuse the bottles, even if apparently intact. Scrupulously respect the prescribed quantities without exceeding the recommended dosages.
Treatment Program
The duration and frequency of administration of Glucose 5% Solution for Intravenous Infusion must be established by the doctor based on the specific needs of the patient. In cases of acute or emergency hypoglycemia, the solution can be infused quickly until the desired glycemic levels are restored. In chronic or supportive conditions, administration may include daily infusions, spaced based on the patient's condition and total fluid and energy needs.
During prolonged therapies, the treatment program must be constantly re-evaluated through clinical and laboratory monitoring of glycemic parameters, renal function and electrolytes. In patients requiring total parenteral nutrition, Glucose 5% can be administered as an integral part of a combination with solutions of amino acids, lipids and mineral salts. In acute situations, the speed of the infusion can be increased, while in maintenance treatments the pace will be slower to ensure an optimal water balance.
Generally, treatment is personalized according to the patient's clinical response, underlying pathology, age, weight and metabolism. Frequent checks and therapeutic adjustments are expected in the event of the appearance of undesirable effects, alterations in vital parameters or changes in the patient's general condition.
Target Species
This solution is intended for use in human patients, including adults, the elderly and children, according to individual clinical guidelines and needs. Its versatility allows it to be used in numerous areas of medical practice, from intensive care to emergency medicine, from pediatrics to geriatrics. The infusion must always be set and monitored by qualified healthcare personnel, with particular caution in vulnerable patient categories such as newborns, young children and patients with multiple pathologies. Use in different age groups and clinical conditions requires careful medical evaluation to adapt volume, speed and any pharmacological additions to the specific situation.
